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    Tenofovir disoproxil fumarate is a prodrug of tenofovir that inhibits the activity of HIV-1 reverse transcriptase and hepatitis B virus (HBV) reverse transcriptase by competing with deoxyadenosine 5?-triphosphate and by DNA chain termination after incorporation into DNA.
    Epivir is for treating HIV, which causes the acquired immunodeficiency syndrome (AIDS). It is not a cure for HIV or AIDS. Epivir-HBV is for treating hepatitis B. Epivir-HBV should not be used in people who are infected with both hepatitis B and HIV.
    3TC belongs to a group of drugs called nucleoside analogues. 3TC interferes with an enzyme called reverse transcriptase (RT), which is used by HIV-infected cells to make new viruses. Since 3TC inhibits, or reduces, the activity of this enzyme, this drug causes HIV-infected cells to produce less HIV.
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    Lopinavir is a protease inhibitor. The amount of Lopinavir in the blood stream stays much higher if it is taken with a small amount of ritonavir, another protease inhibitor. See Fact Sheet 442 for more information on ritonavir. Kaletra is a combination of lopinavir and ritonavir in the same tablet.
    Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body.
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