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    The drug dramatically reduced cholesterol levels and was well tolerated. No tumors were detected. In November 1986, Merck sent the New Drug Application (NDA) to the U.S. FDA and lovastatin was given FDA approval to become the first commercial statin in September 1987.
    In the 1970s the Japanese microbiologist Akira Endo first discovered natural products with a powerful inhibitory effect on HMGR in a fermentation broth of Penicillium citrinum, during his search for antimicrobial agents. The first product was named compactin (ML236B or mevastatin).
    Given that cholesterol is biosynthesized in the early morning hours, the US Food and Drug Administration (FDA) has recommended evening administration for statins with shorter half-lives (lovastatin 2 hours, simvastatin < 5 hours, and fluvastatin < 3 hours).
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    Lovastatin comes as a tablet and an extended-release (long-acting) tablet to take by mouth. The regular tablet usually is taken once or twice a day with meals. The extended-release tablet usually is taken once a day at bedtime. Take lovastatin at around the same time(s) every day.
    Stop taking lovastatin and call your doctor at once if you have any of these serious side effects: unexplained muscle pain, tenderness, or weakness; fever, unusual tiredness, and dark colored urine; chest pain; confusion, memory problems; swelling, weight gain, urinating less than usual or not at all;
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